PetParadise Health Clonidine for dogs: Uses, dosage, and side effects

Clonidine for dogs: Uses, dosage, and side effectsClonidine for dogs: Uses, dosage, and side effects


Clonidine is a medication used to treat high blood pressure in humans. However, veterinarians also prescribe clonidine for dogs to manage a variety of conditions, most commonly anxiety. Like any drug, clonidine can have side effects so understanding proper dosing and potential risks is key.

Keep reading to learn more about uses of clonidine for dogs, typical dosages, and possible adverse effects to monitor.


What is Clonidine?

Clonidine belongs to the drug class called alpha-2 adrenergic agonists. It stimulates receptors in the brain that regulate blood pressure, inhibitory neurotransmitters, and other autonomic nervous system functions.

In humans, clonidine treats hypertension by decreasing sympathetic nervous system activity. The drug was first approved for humans in 1974 but now has many veterinary applications for dogs as well.


Uses of Clonidine in Dogs

While not FDA approved for veterinary use, clonidine is prescribed by vets in an extra-label manner for several off-label indications in dogs:

  • Anxiety – Clonidine has a calming, anti-anxiety effect. It’s often used for noise phobias, separation anxiety, and generalized anxiety in dogs.
  • Pain management – Clonidine provides mild analgesic effects. It may be incorporated into pain control protocols.
  • Anesthesia/sedation – Clonidine’s sedating properties can make anesthesia safer and require less anesthetic drugs.
  • Blood pressure control – Though less common, clonidine may help manage hypertension in dogs.
  • Detoxification – Clonidine can reduce withdrawal signs during detox from opioids or other medications.
  • Compulsive disorders – Clonidine may reduce obsessive behavioral symptoms like licking or tail chasing.

Clonidine is not a frontline drug but rather an “augmenting agent” vets add to enhance other pharmaceutical or behavioral treatments. Careful dosing is imperative.


Appropriate Dosage of Clonidine for Dogs

Clonidine is available as 0.1, 0.2, or 0.3 mg tablets. The typical clonidine dosage for dogs is 0.1 mg per 25 pounds of body weight orally 2-3 times per day.

Clonidine is also compounded into a transdermal gel that is applied to the dog’s inner ear once daily. Adjunct pain meds may allow even lower oral doses.

It’s critical to start with a conservative dose and gradually increase under veterinary guidance only if needed. Overdoses of clonidine can rapidly cause dangerous hypotension and sedation.


Monitoring for Side Effects of Clonidine

While useful for many conditions, clonidine can cause adverse reactions in dogs including:

  • Sedation, lethargy, weakness
  • Gastrointestinal signs like vomiting or diarrhea
  • Transient hypotension
  • Bradycardia (slow heart rate)
  • Hypothermia
  • Incontinence
  • Pain or irritation at gel application site

Most effects are mild at proper doses but rarely clonidine toxicity can cause severe low blood pressure, fainting, and even seizures. Use the lowest effective dose and monitor your dog closely for side effects.


Clonidine Interactions in Dogs

Clonidine should not be combined with additional sedating drugs or medications that also lower blood pressure. Taking clonidine with these agents increases the risk of drug interactions:

  • Acepromazine
  • Tramadol
  • Gabapentin
  • Cymbalta
  • Propranolol
  • NSAID pain relievers

Inform your veterinarian of all supplements and medications your dog takes. Also advise them of any heart, liver, or kidney disease which can alter drug metabolism.


Is Clonidine Safe for Dogs Long-Term?

There are no established safety guidelines for long-term clonidine use in dogs. Potential concerns with sustained use include:

  • Tolerance developing requiring higher doses over time
  • Cardiac effects like bradycardia
  • Risk of rebound hypertension if stopped suddenly after prolonged use
  • Potential kidney damage

Work closely with your veterinarian if clonidine needs to be given longer than 4-6 weeks. Follow up with bloodwork to monitor health effects. Catching side effects promptly allows medication adjustment.



Under veterinary guidance, clonidine can provide therapeutic benefits for many canine health conditions particularly anxiety. However, improper dosing of clonidine for dogs can be hazardous. Monitoring for adverse reactions like lethargy and low blood pressure is crucial, especially when combining clonidine with other medications. Use the lowest effective clonidine dose and keep in close contact with your vet for optimal safety.

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